Glucose metabolism in mouse pancreatic islets
نویسندگان
چکیده
منابع مشابه
Enzymes of glucose metabolism in normal mouse pancreatic islets.
1. Glucose-phosphorylating and glucose 6-phosphatase activities, glucose 6-phosphate dehydrogenase, 6-phosphogluconate dehydrogenase, NADP(+)-linked isocitrate dehydrogenase, ;malic' enzyme and pyruvate carboxylase were assayed in homogenates of normal mouse islets. 2. Two glucose-phosphorylating activities were detected; the major activity had K(m) 0.075mm for glucose and was inhibited by gluc...
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We evaluated the possible autocrine modulatory effect of insulin on glucose metabolism and glucose-induced insulin secretion in islets isolated from normal hamsters. We measured 14CO2 and 3H2O production from d-[U-14C]glucose and d-[5-3H]glucose, respectively, in islets incubated with 0.6, 3.3, 8.3, and 16.7 mM glucose alone or with 5 or 15 mU/ml insulin, anti-insulin guinea pig serum (1:500), ...
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The alpha-anomers of D-glucose and D-mannose stimulate insulin release more efficiently than the corresponding beta-anomers. This coincides with higher glycolytic and oxidative fluxes in pancreatic islets exposed to alpha- than to beta-anomers. This situation may be attributable, in the case of alpha-D-glucose, not solely to the alpha-stereospecificity of phosphoglucose isomerase but also to th...
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1. Rates of insulin secretion, glucose utilization, lactate output, incorporation of glucose into glycogen, contents of glucose 6-phosphate, fructose 1,6-diphosphate and ATP, and maximally extractable enzyme activities of hexokinase, high-K(m) glucose-phosphorylating activity (;glucokinase'), glucose 6-phosphatase and unspecific acid phosphatase were measured in isolated pancreatic islets from ...
متن کاملGlucose metabolism and oscillatory behavior of pancreatic islets.
A variety of oscillations are observed in pancreatic islets. We establish a model incorporating two oscillatory systems of different time scales: One is the well-known bursting model in pancreatic cells and the other is the glucose-insulin feedback model which considers direct and indirect feedback of secreted insulin. These two are coupled to interact with each other in the combined model, and...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1970
ISSN: 0306-3283
DOI: 10.1042/bj1180143